Safety profile and normalization of glycemia of 14 % peripheral dextrose infusion: a prospective observational study
DOI:
https://doi.org/10.32645/13906984.1432Keywords:
Newborn, neonatal hypoglycemia, phlebitis, peripheral catheter, dextroseAbstract
Neonatal hypoglycemia is the leading cause of hospitalization in newborns. The objective of this study was to describe the effect of peripheral infusion of 14% dextrose on normalizing blood glucose and its safety profile. A prospective, single-cohort study was conducted, including episodes of 14% dextrose infusion through a peripheral catheter. A total of 92 infusion episodes in 40 patients were evaluated. The success rate was 97%. 59% required catheter removal: 32% due to infiltration, 25% due to dysfunction, and 3% due to phlebitis. The incidence density of phlebitis was 25 episodes/1000 catheter days. All cases occurred in patients weighing between 1,500 to 2,500 grams, with an incidence of 9.7%, compared to 3% in the total population. The incidence of phlebitis in full-term newborns was 2.4%, compared to 15% in premature infants. In those receiving other medications, the incidence of phlebitis was 6.6%, compared with 2.6% in the group that did not receive other medications, with an incidence ratio of 2.56. Catheter location did not affect the incidence of phlebitis. Peripheral infusion of 14% dextrose was shown to be effective in normalizing blood glucose, with a lower incidence of phlebitis than reported in the literature. Prematurity, low birth weight, and the administration of other medications are associated with a higher incidence of phlebitis.
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